منابع مشابه
Stochastic models of ion channel gating
Stochastic models of ion channel gating date back as far as the pioneering work of Hodgkin and Huxley (1952), whose gating variables are often interpreted as probabilities. Sakmann and Neher directed the efforts that led to the first single-channel recordings, for which they won the Nobel Prize in Physiology and Medicine in 1991. Single-channel recordings (Sakmann and Neher, 1995) demonstrate t...
متن کاملPosition-dependent stochastic diffusion model of ion channel gating.
A position-dependent stochastic diffusion model of gating in ion channels is developed by considering the spatial variation of the diffusion coefficient between the closed and open states. It is assumed that a sensor which regulates the opening of the ion channel experiences Brownian motion in a closed region Rc and a transition region Rm, where the dynamics is described by probability densitie...
متن کاملStochastic Ion Channel Gating and Probabilistic Computation in Dendritic Neurons
H. Cuntz et al. (eds.), The Computing Dendrite: From Structure to Function, Springer Series in Computational Neuroscience 11, DOI 10.1007/978-1-4614-8094-5_24, © Springer Science+Business Media New York 2014 Abstract The electrical signals underlying neural computations are mediated by membrane ion channels. Although these ion channels are well known to operate stochastically, most computationa...
متن کاملCapturing Ion Channel Gating
This is a golden age for ion channels: a time when chemistry, molecular biology, and electrophysiology have come together with structural biology to provide glimpses into some truly amazing membrane proteins. And yet, as usual, the answers yield more questions. Is a new structure the structure of an open channel or of a closed one? How does the voltage sensor actually move? Though providing ama...
متن کاملModels for ion channel gating with compliant states.
In a previous letter to the editor, Sachs and Lecar (1991) described a model for gating of mechanosensitive ion channels. This treatment draws on our "gating-spring" model for gating, which involves an elastic element that conveys force to the channel (Corey and Hudspeth, 1983; Howard and Hudspeth, 1988) and extends it to deal with the elasticity of the channel protein itself. The gating-spring...
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ژورنال
عنوان ژورنال: Scholarpedia
سال: 2008
ISSN: 1941-6016
DOI: 10.4249/scholarpedia.1327